Cobetter Irradiated ATF Hollow Fiber Products
Suspended cell culture technologies primarily encompass three mainstream modes: perfusion culture, fed-batch culture, and batch culture. Currently, the domestic biopharmaceutical industry employs fed-batch culture as the primary production method. However, perfusion processes are gaining increasing attention due to their distinct advantages. Compared to fed-batch systems, perfusion systems enable faster seed cell expansion and maintain long-term stability of high-density cell cultures during the N stage.
By enabling real-time product harvest, perfusion processes significantly enhance production efficiency. Furthermore, this approach ensures consistent product quality while reducing capital investments in production facilities and ancillary equipment.
The core of perfusion technology based on hollow fiber systems lies in establishing a closed cultivation system that integrates an ATF hollow fiber column, tangential flow control systems, and bioreactors. This system effectively retains cells within the cultivation vessel and employs intermittent or continuous medium exchange strategies to create an optimized microenvironment for cell growth.